Gallup looks at the significant cultural contrasts between New Hampshire and South Carolina:
An analysis of more than 350,000 interviews conducted by Gallup in 2008 finds Mississippi, Alabama, South Carolina, Tennessee, Louisiana, and Arkansas to be the most religious states in the nation. Vermont, New Hampshire, Maine, and Massachusetts are the least religious states.
... The United States is generally a religious nation, although the degree of this religiosity varies across states and regions of the country. A robust 65% of all Americans (across the entire U.S. population) reported in 2008 that religion was important in their daily lives.
... Additionally, at least half of the residents of all but four states (Vermont, New Hampshire, Maine, and Massachusetts) say religion is important in their daily lives.
This hasn't stopped some groups in New England, such as the Freedom From Religion Foundation, from taking out ads in Rhode Island which read: "Keep Religion Out of Politics."